A fraternity prank turns into more than these two college boys bargained for. Jimmy and Kyle get caught red handed in Miss Heather's panty drawer. The Chi Alpha Chi girls decide it might be fun to transform the two into sissy sluts since they seem to like panties so much! Meet Giselle and Kylie... the new girls on campus! No more history and biology for these two… it’s now all about high-heels, short skirts, and lipstick!   The cute boy-to-girl couple get to be much more than just roommates. They’ll have to kiss and suck each other while the real sorority sisters watch their humiliation. Miss Heather thinks it’s a good idea for the new girls to get some real world experience by putting out for some of the more popular jocks!

While all the other boys were reading comic books, Devin was leafing through the pages of Priss Magazine imagining himself prancing down the gleaming fashion runways in the highest of high heels and haughtiest of haute couture. Later, he gets a job in the Priss mailroom and finally gets to meet his powerful, and beautiful heroine, Miss Miranda Prissi.

At least six young males have gone missing without a trace in the last three months. Now it's up to Detectives Selleck and Malone to crack the case. Their captain, Sandy Walker is riding their asses for some leads.